X0609 4 2026-10-01 0 0001576280 Guardant Health, Inc. GH 0001927831 Kalia Kumud false 3100 HANOVER STREET PALO ALTO CA 94304 0 1 0 0 Chief Information Officer 0 Common Stock 2026-10-01 4 M 0 1607 0 A 41401 D Common Stock 2026-10-01 4 M 0 1084 0 A 42485 D Common Stock 2026-10-01 4 M 0 1995 0 A 44480 D Common Stock 2026-10-01 4 M 0 1360 0 A 45840 D Common Stock 2026-10-01 4 F 0 3067 174.75 D 42773 D Restricted Stock Units 0 2026-10-01 4 M 0 1607 0 D Common Stock 1607 0 D Restricted Stock Units 0 2026-10-01 4 M 0 1084 0 D Common Stock 1084 0 D Restricted Stock Units 0 2026-10-01 4 M 0 1995 0 D Common Stock 1995 7978 D Restricted Stock Units 0 2026-10-01 4 M 0 1360 0 D Common Stock 1360 8162 D These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability. This represents a restricted stock unit award granted on November 7, 2022 that vested over a four-year period. 25% of the shares subject to such award vested on October 1, 2023 and the remaining 75% of the shares vested in equal quarterly installments over the remaining three-year period thereafter. Not applicable for Restricted Stock Units. This represents a restricted stock unit award granted on December 13, 2023 that vested over a three-year period. 33% of the shares subject to such award vested on October 1, 2024 and the remaining 67% of the shares vested in equal quarterly installments over the remaining two-year period thereafter. This represents a restricted stock unit award granted on November 8, 2024 that vests over a three-year period. 33% of the shares subject to such award vested on October 1, 2025 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. This represents a restricted stock unit award granted on March 12, 2025 that vests over a three-year period. 33% of the shares subject to such award vested on April 1, 2026 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. /s/ John G. Saia, as attorney-in-fact for Kumud Kalia 2026-10-02