X0508 4 2025-12-08 0 0001576280 Guardant Health, Inc. GH 0001927831 Kalia Kumud 3100 HANOVER STREET PALO ALTO CA 94304 0 1 0 0 Chief Information Officer 0 Common Stock 2025-12-08 4 S 0 2000 104.6021 D 22365 D Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $104.58 to $104.75. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. /s/ John G. Saia, as attorney-in-fact for Kumud Kalia 2025-12-10