X0508 4 2025-12-12 0001408443 Milestone Pharmaceuticals Inc. MIST 0001910985 Bharucha David C/O MILESTONE PHARMACEUTICALS INC. 1111 DR. FREDERIK-PHILIPS BLVD, STE 420 MONTREAL A8 H4M 2X6 QUEBEC, CANADA false true false false Chief Medical Officer 0 Common Shares 2025-12-12 4 A 0 100000 A 163333 D Common Shares 2025-12-15 4 S 0 58007 2.32 D 105326 D Common Shares 2026-01-26 4 M 0 20100 A 125426 D Common Shares 2026-01-26 4 S 0 12245 1.93 D 113181 D Employee Stock Option (right to buy) 1.74 2025-12-12 4 A 0 100000 0 A 2034-05-06 Common Shares 100000 100000 D Restricted Stock Units 2026-01-26 4 M 0 20100 0 D Common Shares 20100 60300 D Represents a performance stock unit ("PSU") award that vested upon the certification by the Compensation Committee of the Board of Directors of the Issuer that the U.S. Food and Drug Administration has provided a New Drug Application Approval Letter granting approval of Cardamyst (etripamil). Each PSU represents a contingent right to receive one common share. Represents shares sold pursuant to a sell-to-cover arrangement for the purpose of satisfying income tax liabilities incurred upon vesting of PSUs or restricted stock unit ("RSU") awards only, respectively. The price reported is a weighted average price. These shares were sold in multiple transactions. The Reporting Person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Each RSU represents a contingent right to receive one common share. 50% of the option will vest on June 12, 2026 and 50% will vest on December 12, 2026, subject to the Reporting Person continuing to provide service through each such date. One-fourth (1/4th) of the shares subject to the RSU award vested or will vest on each of January 26, 2026, January 26, 2027, January 26, 2028 and January 26, 2029, subject to the Reporting Person continuing to provide service through each such date. /s/ Joseph Oliveto, Attorney-in-Fact 2026-01-28