X0508 4 2026-01-29 0 0001434647 ZEVRA THERAPEUTICS, INC. ZVRA 0001910132 Quartel Adrian W C/O ZEVRA THERAPEUTICS, INC. 1180 CELEBRATION BOULEVARD, SUITE 103 CELEBRATION FL 34747 0 1 0 0 Chief Medical Officer 1 Common Stock 2026-01-30 4 M 0 11333 A 14256 D Common Stock 2026-01-30 4 S 0 4533 8.8321 D 9723 D Restricted Stock Unit 2026-01-29 4 A 0 37500 0 A Common Stock 37500 37500 D Stock Option (right to buy) 8.86 2026-01-29 4 A 0 75000 0 A 2036-01-28 Common Stock 75000 75000 D Restricted Stock Unit 2026-01-30 4 M 0 11333 0 D Common Stock 11333 22667 D Each restricted stock unit represents a contingent right to receive one share of the Issuer's common stock. Adoption date of referenced 10b5-1(c) plan is: 3/26/2025. This transaction was executed in multiple trades at prices ranging from $8.62 to $9.04. The price reported reflects the weighted average sale price. The Reporting Person undertakes to provide upon request to the SEC staff, the Issuer or any security holder of the Issuer full information regarding the number of shares and prices at which the transaction was effected. The restricted stock units will vest and settle as to one third of the restricted stock units on January 29, 2027, and the remaining two thirds of the restricted stock units will vest and settle in equal annual installments thereafter, subject in each case to the Reporting Person's continued service through such vesting date. Grant to the Reporting Person of a stock option under the Issuer's Amended and Restated 2014 Equity Incentive Plan. The option will vest and become exercisable in four equal annual installments beginning on the first anniversary of the grant date, subject to the Reporting Person's continued service on such vesting date. One third of the restricted stock units vested and settled on January 30, 2026. The remaining two thirds of the restricted stock units will vest and settle in equal annual installment thereafter, subject in each case to the Reporting Person's continued service through such vesting date. /s/ Timothy J. Sangiovanni, Attorney-in-Fact for Adrian W. Quartel 2026-02-02