X0508 4 2025-12-31 0 0001649094 Vaxcyte, Inc. PCVX 0001886794 Dhaliwal Harpreet S. C/O VAXCYTE, INC. 825 INDUSTRIAL ROAD, STE. 300 SAN CARLOS CA 94070 0 1 0 0 Chief Technical Ops Officer 0 Common Stock 2025-12-31 4 S 0 9743 46.689 D 23928 D The price reported is a weighted-average price. The shares were sold at prices ranging from $46.42 to $47.155. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. Includes one (1) share acquired on November 17, 2025 under the Issuer's Employee Stock Purchase Plan. Harpreet S. Dhaliwal, by /s/ Peter N. Efremenko, Attorney-In-Fact 2026-01-02