X0508 4 2025-11-21 0 0001668397 Medpace Holdings, Inc. MEDP 0001877121 Brady Kevin M. C/O MEDPACE HOLDINGS, INC. 5375 MEDPACE WAY CINCINNATI OH 45227 0 1 0 0 CFO & Treasurer 0 Common Stock 2025-11-21 4 M 0 3000 166.73 A 9000 D Common Stock 2025-11-21 4 S 0 3000 590.35 D 6000 D Common Stock 2025-11-21 4 G 0 170 0 D 5830 D Employee Stock Option (Right to Buy) 166.73 2025-11-21 4 M 0 3000 0 D 2026-10-27 Common Stock 3000 0 D The transactions reported on this line were effected pursuant to a limit order placed by the Reporting Person during an open window period. The reported price is a weighted average price. These shares were sold in multiple transactions ranging from $590.00 to $590.72. The Reporting Person undertakes to provide full pricing information to the Issuer, any security holder of the Issuer or the staff of the Securities and Exchange Commission upon request. On November 21, 2025, the Reporting Person gifted 170 shares of common stock to a donor-advised fund. The option vested in full on October 27, 2025. /s/ Stephen P. Ewald, Attorney-in-Fact for Kevin M. Brady 2025-11-25