X0508 4 2025-12-05 0 0001576280 Guardant Health, Inc. GH 0001871615 Freeman Chris 3100 HANOVER STREET PALO ALTO CA 94304 0 1 0 0 Chief Commercial Officer 0 Common Stock 2025-12-05 4 S 0 478 101.4277 D 56961 D Common Stock 2025-12-05 4 S 0 744 102.306 D 56217 D Common Stock 2025-12-05 4 S 0 372 103.4815 D 55845 D Common Stock 2025-12-05 4 S 0 244 104.0985 D 55601 D Common Stock 2025-12-05 4 S 0 228 106.6322 D 55373 D Common Stock 2025-12-05 4 S 0 4084 101.4027 D 51289 D Common Stock 2025-12-05 4 S 0 11969 102.0946 D 39320 D Common Stock 2025-12-05 4 S 0 3414 103.2528 D 35906 D Common Stock 2025-12-05 4 S 0 6555 103.9717 D 29351 D Common Stock 2025-12-05 4 S 0 400 105.9863 D 28951 D Common Stock 2025-12-05 4 S 0 2964 106.7081 D 25987 D Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $100.770 to $101.750. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $101.810 to $102.700. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $103.005 to $103.860. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $104.010 to $104.200. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $106.450 to $106.735. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $100.710 to $101.695. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $101.720 to $102.700. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $102.720 to $103.710. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $103.725 to $104.510. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $105.415 to $106.390. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $106.500 to $106.990. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. /s/ John G. Saia, as attorney-in-fact for Chris Freeman 2025-12-08