X0609 4 2026-10-01 0 0001867096 Xeris Biopharma Holdings, Inc. XERS 0001875714 Pieper Steven false C/O XERIS BIOPHARMA HOLDINGS, INC. 1375 WEST FULTON STREET, SUITE 1300 CHICAGO IL 60607 0 1 0 0 See Remarks 1 Common Stock 2026-10-01 4 S 0 5000 9.4073 D 1351053 D The transaction was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on August 18, 2025. The price reported is a weighted average price. These shares were sold in multiple transactions at prices ranging from $9.210 to $9.670, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range. Chief Financial Officer /s/ Beth Hecht, Attorney-in-Fact 2026-10-02