X0609 4 2026-08-01 0 0001867096 Xeris Biopharma Holdings, Inc. XERS 0001553595 Shannon John Patrick Jr false C/O XERIS BIOPHARMA HOLDINGS, INC. 1375 WEST FULTON STREET, SUITE 1300 CHICAGO IL 60607 1 1 0 0 See Remarks 0 Common Stock 2026-08-01 4 F 0 36645 8.08 D 2898933 D Represents shares that have been withheld by the Issuer to satisfy its income tax and withholding and remittance obligations in connection with the net settlement of restricted stock units vested as of August 1, 2026. Chief Executive Officer and Chairman of the Board /s/ Beth Hecht, Attorney-in-Fact 2026-08-21