X0609 4 2026-08-01 0 0001867096 Xeris Biopharma Holdings, Inc. XERS 0002031695 McCulloch Kevin false C/O XERIS BIOPHARMA HOLDINGS, INC. 1375 WEST FULTON STREET, SUITE 1300 CHICAGO IL 60607 0 1 0 0 See Remarks 0 Common Stock 2026-08-01 4 F 0 21918 8.08 D 1654208 D Common Stock 25000 I By Spouse Represents shares that have been withheld by the Issuer to satisfy its income tax and withholding and remittance obligations in connection with the net settlement of restricted stock units vested as of August 1, 2026. The reporting person disclaims beneficial ownership of these securities except to the extent of his pecuniary interest therein, and the inclusion of these shares in this report shall not be deemed an admission of beneficial ownership of all of the reported shares for purposes of Section 16 or for any other purpose. President and Chief Operating Officer /s/ Beth Hecht, Attorney-in-Fact 2026-08-21