X0508 4 2025-12-16 0 0000879407 ARROWHEAD PHARMACEUTICALS, INC. ARWR 0001826263 Vakiener Victoria 177 E COLORADO BLVD SUITE 700 PASADENA CA 91105 1 0 0 0 0 Common Stock 2025-12-16 4 A 0 7819 0 A 45763 D Represents shares underlying restricted stock units, which shares will vest in one installment on the first anniversary of the grant date, subject to the Reporting Person's continued service to the Issuer on such date. /s/Victoria Vakiener 2025-12-18