X0609 4 2026-08-31 0 0001649094 Vaxcyte, Inc. PCVX 0001813798 Wassil Jim false C/O VAXCYTE, INC. 825 INDUSTRIAL ROAD, STE. 300 SAN CARLOS CA 94070 0 1 0 0 CHIEF OPERATING OFFICER 0 Common Stock 2026-08-31 4 F 0 1273 60.74 D 156268 D Common Stock 2026-09-01 4 M 0 2250 5.35 A 158518 D Common Stock 2026-09-01 4 S 0 1537 60.886 D 156981 D Common Stock 2026-09-01 4 S 0 713 61.481 D 156268 D Common Stock 2026-09-01 4 S 0 924 60.955 D 155344 D Common Stock 2026-09-01 4 S 0 303 61.424 D 155041 D Common Stock 2026-09-02 4 F 0 1432 61.58 D 153609 D Stock Option (right to buy) 5.35 2026-09-01 4 M 0 2250 0 D 2030-04-17 Common Stock 2250 66648 D Represents shares surrendered to the Issuer to cover applicable tax withholding obligations realized upon the vesting of RSUs. The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on December 9, 2025. The price reported is a weighted-average price. The shares were sold at prices ranging from $60.29 to $61.275. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. The price reported is a weighted-average price. The shares were sold at prices ranging from $61.31 to $62.04. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. The price reported is a weighted-average price. The shares were sold at prices ranging from $60.29 to $61.22. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. The price reported is a weighted-average price. The shares were sold at prices ranging from $61.34 to $61.48. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. Stock Option is fully vested and exercisable. Jim Wassil, by /s/ Peter N. Efremenko, Attorney-In-Fact 2026-09-02