X0508 4 2026-03-09 0 0001649094 Vaxcyte, Inc. PCVX 0001813798 Wassil Jim C/O VAXCYTE, INC. 825 INDUSTRIAL ROAD, STE. 300 SAN CARLOS CA 94070 0 1 0 0 CHIEF OPERATING OFFICER 1 Common Stock 2026-03-09 4 F 0 975 59.32 D 174213 D Common Stock 2026-03-10 4 S 0 2427 58.316 D 171786 D Common Stock 2026-03-10 4 S 0 4968 59.16 D 166818 D Represents shares surrendered to the Issuer to cover applicable tax withholding obligations realized upon the vesting of RSUs. No other shares of common stock subject to the restrictions on transfer set forth in a Lock-Up Agreement dated January 29, 2026 were sold by the Reporting Person. The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted on December 9, 2025. The price reported is a weighted-average price. The shares were sold at prices ranging from $57.725 to $58.715. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. The price reported is a weighted-average price. The shares were sold at prices ranging from $58.74 to $59.575. The reporting person will provide upon request to the SEC, the issuer or security holder of the issuer, full information regarding the number of shares sold at each separate price. Jim Wassil, by /s/ Peter N. Efremenko, Attorney-In-Fact 2026-03-11