X0508 4 2026-02-09 0 0001490978 Schrodinger, Inc. SDGR 0001798179 Abel Robert Lorne C/O SCHRODINGER, INC., 1540 BROADWAY, 24TH FLOOR NEW YORK NY 10036 0 1 0 0 See Remarks 1 Common Stock 2026-02-09 4 S 0 1230 13.51 D 19385 D This sale was effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on June 13, 2023, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units ("RSUs"). The sale does not represent a discretionary trade by the reporting person. Includes 15,137 unvested RSUs. EVP, Chief Scientific Officer, Platform /s/ Donald Shum, as attorney-in-fact for Robert Lorne Abel 2026-02-11