X0508 4 2026-02-10 0 0001490978 Schrodinger, Inc. SDGR 0001797730 Lorton Kenneth Patrick C/O SCHRODINGER, INC., 1540 BROADWAY, 24TH FLOOR NEW YORK NY 10036 0 1 0 0 EVP, CTO & COO, Software 1 Common Stock 2026-02-10 4 S 0 925 13.7338 D 52651 D This sale was effected pursuant to a durable automatic sale instruction under Rule 10b5-1 adopted by the reporting person on March 9, 2023, and represents a broker-assisted sale of shares to satisfy the payment of withholding tax liability incurred upon the vesting of restricted stock units ("RSUs"). The sale does not represent a discretionary trade by the reporting person. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $13.625 to $13.8575, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the U.S. Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote (2) of this Form 4. Includes 14,543 unvested RSUs. /s/ Donald Shum, as attorney-in-fact for Kenneth Patrick Lorton 2026-02-12