<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0508</schemaVersion>

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    <periodOfReport>2026-03-04</periodOfReport>

    <notSubjectToSection16>1</notSubjectToSection16>

    <issuer>
        <issuerCik>0001851194</issuerCik>
        <issuerName>Ventyx Biosciences, Inc.</issuerName>
        <issuerTradingSymbol>VTYX</issuerTradingSymbol>
    </issuer>

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            <rptOwnerCik>0001778739</rptOwnerCik>
            <rptOwnerName>White William Richard</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O VENTYX BIOSCIENCES, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>12790 EL CAMINO REAL, SUITE 200</rptOwnerStreet2>
            <rptOwnerCity>SAN DIEGO</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>92130</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle></officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

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    <nonDerivativeTable></nonDerivativeTable>

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            <securityTitle>
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            </securityTitle>
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                <transactionShares>
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                <transactionPricePerShare>
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            <expirationDate>
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        <derivativeTransaction>
            <securityTitle>
                <value>Stock Option (Right to Buy)</value>
            </securityTitle>
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        </derivativeTransaction>
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    <footnotes>
        <footnote id="F1">Pursuant to the Agreement and Plan of Merger, dated January 7, 2026 (as it may be amended from time to time, the &quot;Merger Agreement&quot;), by and among Ventyx Biosciences, Inc. (&quot;Issuer&quot;) , Eli Lilly and Company (&quot;Parent&quot;), and Parent's wholly owned subsidiary, RYLS Merger Corporation ( &quot;Merger Sub&quot;), the Merger Sub merged with and into the Issuer (the &quot;Merger&quot;), with the Issuer surviving the Merger and becoming a wholly owned subsidiary of the Parent.</footnote>
        <footnote id="F2">At the effective time of the Merger (the &quot;Effective Time&quot;), this option to purchase shares of the Issuer's common stock had an exercise price per share that was less than or equal to $14.00 (without interest) per share (the &quot;Per Share Price&quot;) and, pursuant to the terms of the Merger Agreement, at the Effective Time, was automatically cancelled and converted into the right to receive an amount in cash equal to (i) the total number of shares of common stock subject to the option, multiplied by (ii) the excess, if any, of the Per Share Price over the exercise price per share of such option, without interest and less any applicable withholding taxes.</footnote>
        <footnote id="F3">At the Effective Time, this option to purchase shares of the Issuer's common stock was fully vested and had an exercise price per share that was greater than the Per Share Price and, pursuant to the terms of the Merger Agreement, at the Effective Time, was automatically cancelled for no consideration.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Austin Rutherford, as Attorney-in-Fact</signatureName>
        <signatureDate>2026-03-04</signatureDate>
    </ownerSignature>
</ownershipDocument>
