X0508 4 2025-12-09 0001408443 Milestone Pharmaceuticals Inc. MIST 0001771207 Muller Lorenz C/O MILESTONE PHARMACEUTICALS INC. 1111 DR. FREDERIK-PHILIPS BLVD, STE 420 MONTREAL A8 H4M 2X6 QUEBEC, CANADA false true false false Chief Commercial Officer 0 Common Shares 2025-12-09 4 G 0 25000 0 D 150052 D Represents a bona fide gift for no consideration to members of the Reporting Person's family outside the Reporting Person's household. /s/ Joseph Oliveto, Attorney-in-Fact 2025-12-11