X0609 4 2026-09-22 0001628171 Revolution Medicines, Inc. RVMD 0001758247 ANDERSON ELIZABETH M false C/O REVOLUTION MEDICINES, INC. 700 SAGINAW DRIVE REDWOOD CITY CA 94063 true false false false true Common Stock 2026-09-22 4 M false 5070 1.12 A 14476 D Common Stock 2026-09-22 4 S false 910 191.8521 D 13566 D Common Stock 2026-09-22 4 S false 4985 192.5387 D 8581 D Common Stock 2026-09-22 4 S false 2648 193.4392 D 5933 D Common Stock 2026-09-22 4 S false 1500 194.5887 D 4433 D Common Stock 2026-09-22 4 S false 100 195.15 D 4333 D Common Stock 26990 I See footnote Common Stock 15000 I See footnote Stock Option (Right to Buy) 1.12 2026-09-22 4 M false 5070 0 D 2028-04-19 Common Stock 6165 1095 D Transaction made pursuant to a 10b5-1 trading plan adopted by the Reporting Person on June 23, 2026. The transaction was executed in multiple trades at prices ranging from $191.65 to $191.99, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. The transaction was executed in multiple trades at prices ranging from $192.01 to $192.99, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. The transaction was executed in multiple trades at prices ranging from $193.00 to $193.81, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. The transaction was executed in multiple trades at prices ranging from $194.04 to $194.96, inclusive. The price reported in Column 4 above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the Securities and Exchange Commission staff, the Issuer, or a security holder of the Issuer, upon request, full information regarding the number of shares sold at each respective price within the range set forth in this footnote. Includes 1,191 restricted stock units. Held by David W. Anderson 1996 Irrevocable Trust. Held by Irrevocable Deed of Trust of David W. Anderson and Elizabeth M. Anderson. Fully vested. /s/ Jack Anders, as Attorney-in-fact for Elizabeth M. Anderson 2026-09-24