X0609 4 2026-08-21 0 0001576280 Guardant Health, Inc. GH 0001753159 Talasaz AmirAli false 3100 HANOVER STREET PALO ALTO CA 94304 1 1 0 0 Co-Chief Executive Officer 0 Common Stock 2026-08-21 4 S 0 9023 168.1958 D 65977 I Shares held by the Talasaz Family Foundation Common Stock 2026-08-21 4 S 0 20888 169.1618 D 45089 I Shares held by the Talasaz Family Foundation Common Stock 2026-08-21 4 S 0 7589 170.2862 D 37500 I Shares held by the Talasaz Family Foundation Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $167.81 to $168.60. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $168.87 to $169.73. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $169.88 to $170.50. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. /s/ John G. Saia, as attorney-in-fact for AmirAli Talasaz 2026-08-24