X0609 4 2026-09-30 0 0001576280 Guardant Health, Inc. GH 0001752968 Eltoukhy Helmy false 3100 HANOVER STREET PALO ALTO CA 94304 1 1 0 0 Co-Chief Executive Officer 0 Common Stock 2026-09-30 4 M 0 2817 0 A 1943751 I Shares held by Helmy A. Eltoukhy Revocable Trust Common Stock 2026-09-30 4 F 0 1428 178.36 D 1942323 I Shares held by Helmy A. Eltoukhy Revocable Trust Common Stock 2026-10-01 4 M 0 23997 0 A 1966320 I Shares held by Helmy A. Eltoukhy Revocable Trust Common Stock 2026-10-01 4 M 0 9716 0 A 1976036 I Shares held by Helmy A. Eltoukhy Revocable Trust Common Stock 2026-10-01 4 F 0 17087 174.75 D 1958949 I Shares held by Helmy A. Eltoukhy Revocable Trust Restricted Stock Units 0 2026-09-30 4 M 0 2817 0 D Common Stock 2817 2817 D Restricted Stock Units 0 2026-10-01 4 M 0 23997 0 D Common Stock 23997 23998 D Restricted Stock Units 0 2026-10-01 4 M 0 9716 0 D Common Stock 9716 48580 D These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability. This represents a restricted stock unit award granted on March 17, 2026 that vests in four equal installments on the last day of each calendar quarter, March 31, 2026, June 30, 2026, September 30, 2026, and December 31, 2026. Not applicable for Restricted Stock Units. This represents a restricted stock unit award granted on March 18, 2024 that vests over a three-year period. 33% of the shares subject to such award vested on January 1, 2025 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. This represents a restricted stock unit award granted on March 12, 2025 that vests over a three-year period. 33% of the shares subject to such award vested on January 1, 2026 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. /s/ John G. Saia, as attorney-in-fact for Helmy Eltoukhy 2026-10-02