X0508 4 2025-11-10 0 0001321732 Penumbra Inc PEN 0001751980 Roberts Johanna ONE PENUMBRA PLACE ALAMEDA CA 94502 0 1 0 0 EVP, Gen. Counsel & Secretary 1 Common Stock 2025-11-10 4 S 0 11 263.58 D 64246 D Common Stock 2025-11-10 4 S 0 13 264.89 D 64233 D Common Stock 2025-11-10 4 S 0 168 265.93 D 64065 D Common Stock 2025-11-10 4 S 0 211 266.72 D 63854 D Common Stock 2025-11-10 4 S 0 85 267.56 D 63769 D Common Stock 2025-11-10 4 S 0 76 269.01 D 63693 D Common Stock 2025-11-10 4 S 0 36 269.56 D 63657 D The sales were effected pursuant to the Reporting Person's Rule 10b5-1 trading plan. This transaction was executed in multiple trades at prices ranging from $263.25 to $264.21. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the SEC staff, the Issuer or a security holder of the Issuer, upon request, full information regarding the number of shares and prices at which the transaction was effected. A portion of these shares is subject to vesting. This transaction was executed in multiple trades at prices ranging from $264.34 to $265.15. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the SEC staff, the Issuer or a security holder of the Issuer, upon request, full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $265.33 to $266.24. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the SEC staff, the Issuer or a security holder of the Issuer, upon request, full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $266.25 to $267.20. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the SEC staff, the Issuer or a security holder of the Issuer, upon request, full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $267.26 to $268.23. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the SEC staff, the Issuer or a security holder of the Issuer, upon request, full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $268.73 to $269.23. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the SEC staff, the Issuer or a security holder of the Issuer, upon request, full information regarding the number of shares and prices at which the transaction was effected. This transaction was executed in multiple trades at prices ranging from $269.25 to $269.94. The price reported above reflects the weighted average sale price. The Reporting Person hereby undertakes to provide to the SEC staff, the Issuer or a security holder of the Issuer, upon request, full information regarding the number of shares and prices at which the transaction was effected. /s/ Johanna Roberts 2025-11-12