X0609 4 2026-07-01 0 0001867096 Xeris Biopharma Holdings, Inc. XERS 0001741850 KREHER NERISSA false C/O XERIS BIOPHARMA HOLDINGS, INC. 1375 WEST FULTON STREET, SUITE 1300 CHICAGO IL 60607 1 0 0 0 0 Common Stock 2026-07-01 4 A 0 33582 0 A 33582 D Stock Option (Right to Buy) 8 2026-07-01 4 A 0 37910 8 A 2036-07-01 Common Stock 37910 37910 D These shares were acquired pursuant to a restricted stock unit grant under the Company's 2018 Stock Option and Incentive Plan (the "Plan"). Each restricted stock represents a contingent right to receive one share of the Company's common stock. These shares shall vest in equal annual installments over three years, subject to continued service on the Company's Board of Directors through such vesting date. These stock options were acquired pursuant to a grant under the Plan. These stock options shall vest in equal annual installments over three years, subject to continued service on the Company's Board of Directors through such vesting date. Director /s/ Beth Hecht, Attorney-in-Fact 2026-07-02