X0508 4 2025-11-17 0 0001651308 BeOne Medicines Ltd. ONC 0001739452 Wu Xiaobin C/O BEONE MEDICINES I GMBH AESCHENGRABEN 27, 21ST FLOOR BASEL V8 4051 SWITZERLAND 0 1 0 0 President and COO 0 Ordinary Shares 968978 D American Depositary Shares 12365 D American Depositary Shares 4000 I By Wife American Depositary Shares 2025-11-17 4 S 0 3155 380.2274 D 836 D American Depositary Shares 2025-11-17 4 S 0 826 381.1891 D 10 D American Depositary Shares 2025-11-17 4 S 0 10 382.32 D 0 D Each American Depositary Share represents 13 Ordinary Shares. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $380.00 to $380.765, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $381.115 to $381.88, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. /s/ Qing Nian, as Attorney-in-Fact 2025-11-19