X0508 4 2025-11-12 0 0001651308 BeOne Medicines Ltd. ONC 0001739452 Wu Xiaobin C/O BEONE MEDICINES I GMBH AESCHENGRABEN 27, 21ST FLOOR BASEL V8 4051 SWITZERLAND 0 1 0 0 President and COO 0 Ordinary Shares 1020861 D American Depositary Shares 12365 D American Depositary Shares 4000 I By Wife American Depositary Shares 2025-11-12 4 S 0 500 350.441 D 15509 D American Depositary Shares 2025-11-12 4 S 0 3240 351.4102 D 12269 D American Depositary Shares 2025-11-12 4 S 0 789 352.7773 D 11480 D American Depositary Shares 2025-11-12 4 S 0 251 354.1964 D 11229 D American Depositary Shares 2025-11-12 4 S 0 120 355 D 11109 D American Depositary Shares 2025-11-12 4 S 0 100 357.4318 D 11009 D American Depositary Shares 2025-11-12 4 S 0 4846 360.0958 D 6163 D American Depositary Shares 2025-11-12 4 S 0 154 362.0719 D 6009 D American Depositary Shares 2025-11-13 4 S 0 4240 380.3261 D 1769 D American Depositary Shares 2025-11-13 4 S 0 1769 381.0497 D 0 D Includes 650 ordinary shares acquired pursuant to the Company's Fourth Amended and Restated 2018 Employee Share Purchase Plan. Each American Depositary Share represents 13 Ordinary Shares. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $350.00 to $350.93, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $351.05 to $351.52, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $352.28 to $353.10, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $353.59 to $354.585, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $357.385 to $357.70, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $360.00 to $360.945, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $362.00 to $362.33, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $380.00 to $380.75, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $381.00 to $381.50, inclusive. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of American Depositary Shares sold at each separate price. /s/ Qing Nian, as Attorney-in-Fact 2025-11-14