<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0508</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2026-02-12</periodOfReport>

    <issuer>
        <issuerCik>0001374310</issuerCik>
        <issuerName>Cboe Global Markets, Inc.</issuerName>
        <issuerTradingSymbol>CBOE</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001732952</rptOwnerCik>
            <rptOwnerName>Sexton John P</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O CBOE GLOBAL MARKETS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>433 WEST VAN BUREN STREET</rptOwnerStreet2>
            <rptOwnerCity>CHICAGO</rptOwnerCity>
            <rptOwnerState>IL</rptOwnerState>
            <rptOwnerZipCode>60607</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>false</isDirector>
            <isOfficer>true</isOfficer>
            <isTenPercentOwner>false</isTenPercentOwner>
            <isOther>false</isOther>
            <officerTitle>EVP, GC AND CORP SEC</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <aff10b5One>0</aff10b5One>

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            </securityTitle>
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                <footnoteId id="F1"/>
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                </transactionShares>
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                <transactionAcquiredDisposedCode>
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                </transactionPricePerShare>
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                </transactionAcquiredDisposedCode>
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                <sharesOwnedFollowingTransaction>
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                </sharesOwnedFollowingTransaction>
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        <nonDerivativeTransaction>
            <securityTitle>
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            </transactionDate>
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                <transactionFormType>4</transactionFormType>
                <transactionCode>A</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
                <footnoteId id="F1"/>
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                    <value>2926</value>
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                <transactionPricePerShare>
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                    <value>A</value>
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                <sharesOwnedFollowingTransaction>
                    <value>29085</value>
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            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
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                    <value></value>
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        </nonDerivativeTransaction>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
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                <sharesOwnedFollowingTransaction>
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                    <value>D</value>
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                <sharesOwnedFollowingTransaction>
                    <value>27891</value>
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        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes>
        <footnote id="F1">Represents shares of the Issuer's common stock issued to the Reporting Person pursuant to the vesting of restricted stock unit awards - performance based (&quot;PSU&quot;) that were awarded to the Reporting Person on February 19, 2023. The issuance was based on the level of achievement by the Issuer of certain pre-established performance metrics for the performance period January 1, 2023 to December 31, 2025 as determined by the Compensation and Human Capital Committee on February 12, 2026.</footnote>
        <footnote id="F2">Represents shares of the Issuer's common stock withheld to satisfy the Issuer's tax withholding obligation upon the vesting of PSUs that were awarded on February 19, 2023 and the issuance of the underlying shares of the Issuer's common stock.</footnote>
        <footnote id="F3">Settlement of dividend equivalent rights in connection with the vesting of underlying PSUs that were awarded to the Reporting Person on February 19, 2023. The rights accrued when and as dividends were paid on the Issuer's common stock. Each dividend equivalent right was the economic equivalent of one share of the Issuer's common stock.</footnote>
        <footnote id="F4">Represents shares of the Issuer's common stock withheld to satisfy the Issuer's tax withholding obligation upon the settlement of dividend equivalent rights in connection with the vesting of underlying PSUs and the issuance of the underlying shares of the Issuer's common stock.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Patrick Sexton</signatureName>
        <signatureDate>2026-02-17</signatureDate>
    </ownerSignature>
</ownershipDocument>
