X0508 4 2025-11-03 0001604821 Natera, Inc. NTRA 0001711968 Chapman Steven Leonard C/O NATERA, INC. 13011 MCCALLEN PASS BUILDING A SUITE 100 AUSTIN TX 78753 true true false false CEO AND PRESIDENT 1 Common Stock 2025-11-03 4 M 0 2084 13.01 A 151924 D Common Stock 2025-11-03 4 M 0 3595 20.27 A 155519 D Common Stock 2025-11-03 4 M 0 150000 119.75 A 305519 D Common Stock 2025-11-03 4 S 0 2215 198.0293 D 303304 D Common Stock 2025-11-03 4 S 0 1915 198.9619 D 301389 D Common Stock 2025-11-03 4 S 0 156573 199.9983 D 144816 D Stock Option (right to buy) 13.01 2025-11-03 4 M 0 2084 0 D 2029-01-10 Common Stock 2084 0 D Stock Option (right to buy) 20.27 2025-11-03 4 M 0 3595 0 D 2029-04-11 Common Stock 3595 0 D Stock Option (right to buy) 119.75 2025-11-03 4 M 0 150000 0 D 2031-01-21 Common Stock 150000 0 D The sale of shares on this form was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 11, 2023, as amended on December 2, 2024. The sale of 150,000 of these shares was governed by the initial plan and not altered by the subsequently amendment. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $197.28 to $198.27 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $198.44 to $199.43 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $199.51 to $200.00 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The option shares are fully exercisable. On January 22, 2021, the Reporting Person was granted performance-based options which vest in tranches upon the achievement of milestones relating to a combination of the passage of time and certain business performance criteria. The performance thresholds were certified on June 28, 2024, March 28, 2025 and September 28, 2025, resulting in the performance-based option being fully vested as of the last performance threshold date. /s/ Vincent Fontanilla, Attorney-in-Fact 2025-11-03