X0508 4 2025-12-22 0001370053 ANAPTYSBIO, INC ANAB 0001711462 Lizzul Paul F. C/O ANAPTYSBIO, INC. 10770 WATERIDGE CIRCLE, SUITE 210 SAN DIEGO CA 92121 false true false false Chief Medical Officer 1 Common Stock 2025-12-22 4 M 0 1500 18.5 A 28467 D Common Stock 2025-12-22 4 S 0 1500 50 D 26967 D Employee Stock Option (right to buy) 18.5 2025-12-22 4 M 0 1500 0 D 2030-07-29 Common Stock 1500 83500 D Includes the acquisition of 1,324 shares acquired under the Company's ESPP. The sale reported on this Form 4 was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on April 14, 2025. The stock option is fully vested. In addition to the remaining options to purchase 83,500 shares of common stock as set forth in Table II, the Reporting Person also holds additional options to purchase up to an aggregate of 394,810 shares of common stock, which options vest according to their terms. /s/ Eric Loumeau, Attorney-in-Fact 2025-12-23