X0508 4 2025-12-15 0 0001576280 Guardant Health, Inc. GH 0001702824 Bell Michael Brian 3100 HANOVER STREET PALO ALTO CA 94304 0 1 0 0 Chief Financial Officer 0 Common Stock 2025-12-15 4 M 0 1233 0 A 29285 D Common Stock 2025-12-15 4 M 0 2039 0 A 31324 D Common Stock 2025-12-15 4 F 0 1659 102.67 D 29665 D Restricted Stock Units 0 2025-12-15 4 M 0 1233 0 D Common Stock 1233 1233 D Restricted Stock Units 0 2025-12-15 4 M 0 2039 0 D Common Stock 2039 4078 D These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability. This represents a restricted stock unit award granted on May 9, 2022 that vests over a four-year period. 25% of the shares subject to such award vested on March 15, 2023 and the remaining 75% of the shares vests in equal quarterly installments over the remaining three-year period thereafter. Not applicable for Restricted Stock Units. This represents a restricted stock unit award granted on June 9, 2023 that vests over a three-year period. 33% of the shares subject to such award vested on June 15, 2024 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. /s/ John G. Saia, as attorney-in-fact for Michael Brian Bell 2025-12-17