X0508 4 2026-02-10 0001427925 TALPHERA, INC. TLPH 0001700225 Angotti Vincent J. C/O TALPHERA, INC. 1850 GATEWAY DRIVE, SUITE 175 SAN MATEO CA 94404 true true false false CHIEF EXECUTIVE OFFICER 0 Common Stock 2026-02-10 4 F 0 3179 0.8361 D 481590 D Common Stock 2026-02-12 4 P 0 105364 0.8123 A 586954 D Common Stock 2026-02-14 4 F 0 9559 0.7934 D 577395 D Stock Option (Right to Buy) 0.8123 2026-02-12 4 A 0 594000 0 A 2036-02-11 Common Stock 594000 594000 D Represents shares surrendered to the Issuer by the Reporting Person to pay required tax withholdings due to the vesting of RSUs. Balance includes non-reportable acquisition of 10,000 shares of Common Stock through the Company's Employee Stock Purchase Plan. The restricted stock units shall vest in three equal consecutive annual installments on February 12, 2027, February 12, 2028 and February 12, 2029. On February 12, 2026, the reporting person was granted an option to purchase 594,000 shares of common stock. One fourth (1/4th) of the option shares shall vest on the one year anniversary of the grant date, and the remaining balance of the option shares shall vest in 36 equal consecutive monthly installments thereafter until fully vested so long as the reporting person remains in continuous service through such applicable vesting periods. /s/ Martha Adler, Attorney-in-Fact 2026-02-20