X0508 4 2026-03-03 0001888886 Structure Therapeutics Inc. GPCR 0001698149 Stevens Raymond C C/O STRUCTURE THERAPEUTICS INC. 601 GATEWAY BLVD., SUITE 900 SOUTH SAN FRANCISCO CA 94080 true true false false CHIEF EXECUTIVE OFFICER 0 Ordinary Shares 2026-03-03 4 F 0 53454 20.99 D 1141376 D Ordinary Shares 1554586 I See footnote American Depositary Shares 2025-11-20 5 A 0 824 0 A Ordinary Shares 2472 1824 D American Depositary Shares Ordinary Shares 12000 4000 I See footnote The Ordinary Shares of the Issuer may be represented by American Depositary Shares ("ADSs"). Each ADS represents three Ordinary Shares of the Issuer. Represents shares withheld by the Issuer to satisfy income tax obligations associated with the vesting of a restricted share unit award. By Raymond Stevens and Vivian Urena-Stevens, as Co-Trustees of the Stevens 2001 Revocable Trust, dated March 28, 2001. Each ADS is convertible at any time, at the holder's election, into three Ordinary Shares of the Issuer. The ADSs have no expiration date. Voluntary reporting of the acquisition of 824 ADSs by the Reporting Person on November 20, 2025 pursuant to the Issuer's Employee Share Purchase Plan. /s/ Jun Yoon, Attorney-in-Fact 2026-03-05