X0508 4 2026-01-20 0001604821 Natera, Inc. NTRA 0001697362 Brophy Michael Burkes C/O NATERA, INC. 13011 MCCALLEN PASS BUILDING A SUITE 100 AUSTIN TX 78753 false true false false CHIEF FINANCIAL OFFICER 1 Common Stock 2026-01-20 4 S 0 23948 234.7384 D 99776 D Common Stock 2026-01-20 4 M 0 1522 A 101298 D Common Stock 2026-01-21 4 S 0 602 235 D 100696 D Common Stock 2026-01-21 4 S 0 36573 242.6685 D 64123 D Restricted Stock Unit 2026-01-20 4 M 0 1522 0 D Common Stock 1522 0 D The sale of shares was effected in order to satisfy tax withholding and remittance obligations in connection with the vesting of Restricted Stock Units (RSUs) and made pursuant to a written instruction that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act contained in the Reporting Person's Stock Unit Agreement granted on January 27, 2023. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The sale of shares was effected in order to satisfy tax withholding and remittance obligations in connection with the vesting of RSUs and made pursuant to a written instruction that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act contained in the Reporting Person's Stock Unit Agreement granted on January 28, 2022. The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 9, 2025, as modified on September 10, 2025. The RSUs vest over four years. 25% of the RSUs vested on January 20, 2023 and the remaining shares vest in 12 equal quarterly installments thereafter. /s/ Tami Chen, Attorney-in-Fact 2026-01-22