X0508 4 2025-11-17 0 0001729427 CNS Pharmaceuticals, Inc. CNSP 0001793252 Gumulka Jerzy C/O CNS PHARMACEUTICALS, INC. 100 WEST LOOP SOUTH, SUITE 900 HOUSTON TX 77027 1 0 0 0 0 Option to purchase common stock 12.48 2025-11-17 4 A 0 1517 0 A 2035-11-17 Common Stock 1517 1517 D The option grant was approved by the compensation committee of CNS Pharmaceutical, Inc.'s board of directors on June 6, 2025, subject to shareholder approval of the stock option plan under which the option was granted. CNS Pharmaceutical, Inc.'s shareholders approved the plan at the company's annual meeting on November 17, 2025 (the "Shareholder Approval Date"). The options set forth in the table vest in four equal quarterly installments commencing on the Shareholder Approval Date, subject to the reporting person's continued employment on each vesting date. Issued in connection with the reporting person's employment with the Company. /s/ Christopher Downs, Attorney-in-Fact 2025-11-19