X0508 4 2025-11-19 0001604821 Natera, Inc. NTRA 0001680739 Baynes Roy D. C/O NATERA, INC. 13011 MCCALLEN PASS BUILDING A SUITE 100 AUSTIN TX 78753 true false false false 1 Common Stock 2025-11-19 4 M 0 5112 40.93 A 23471 D Common Stock 2025-11-19 4 S 0 1250 213.4710 D 22221 D Common Stock 2025-11-19 4 S 0 1727 214.7921 D 20494 D Common Stock 2025-11-19 4 S 0 2135 216.0673 D 18359 D Common Stock 2025-11-20 4 M 0 600 40.93 A 18959 D Common Stock 2025-11-20 4 M 0 7068 41.19 A 26027 D Common Stock 2025-11-20 4 S 0 1184 220.1402 D 24843 D Common Stock 2025-11-20 4 S 0 900 221.8133 D 23943 D Common Stock 2025-11-20 4 S 0 1800 222.90 D 22143 D Common Stock 2025-11-20 4 S 0 1900 223.9037 D 20243 D Common Stock 2025-11-20 4 S 0 1884 224.8860 D 18359 D Stock Option (right to buy) 40.93 2025-11-19 4 M 0 5112 0 D 2030-06-11 Common Stock 5112 600 D Stock Option (right to buy) 40.93 2025-11-20 4 M 0 600 0 D 2030-06-11 Common Stock 600 0 D Stock Option (right to buy) 41.19 2025-11-20 4 M 0 7068 0 D 2032-05-25 Common Stock 7068 0 D The sale of shares was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on August 20, 2025. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $213.18 to $214.1550 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $214.35 to $215.30 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $215.55 to $216.39 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $220.00 to $220.43 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $221.42 to $222.24 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $222.46 to $223.24 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $223.49 to $224.41 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $224.72 to $224.92 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The option shares are fully exercisable. /s/ Vincent Fontanilla, Attorney-in-Fact 2025-11-21