X0508 4 2026-03-02 0001842295 Maze Therapeutics, Inc. MAZE 0001676170 Coloma Jason V C/O MAZE THERAPEUTICS, INC. 171 OYSTER POINT BOULEVARD, SUITE 300 SOUTH SAN FRANCISCO CA 94080 true true false false Chief Executive Officer 0 Stock Option (Right to Buy) 45.61 2026-03-02 4 A 0 150000 0 A 2036-03-01 Common Stock 150000 150000 D Restricted Stock Units 2026-03-02 4 A 0 75000 0 A Common Stock 75000 75000 D The option award shall vest as to 1/48 of the total award monthly, with the first tranche vesting on April 1, 2026, subject to the reporting person's continued service to the Issuer on each vesting date. Each restricted stock unit represents a contingent right to receive one share of the Issuer's Common Stock upon settlement. The restricted stock unit award shall vest in ratable increments of 1/4 of the total award, with the first tranche vesting on March 1, 2027, and vesting thereafter on the one year anniversary of such date, subject to the reporting person's continued service to the Issuer on each vesting date. These restricted stock units do not expire; they either vest or are cancelled prior to the vesting date. /s/ Courtney Phillips, as attorney-in-fact 2026-03-03