X0508 4 2026-01-21 0 0001576280 Guardant Health, Inc. GH 0001652956 Monroe Terilyn J. 3100 HANOVER STREET PALO ALTO CA 94304 0 1 0 0 Chief People Officer 1 Common Stock 2026-01-21 4 S 0 1703 112.3418 D 27858 D Common Stock 2026-01-21 4 S 0 3619 113.4793 D 24239 D Common Stock 2026-01-21 4 S 0 3249 115.6978 D 20990 D Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $111.97 to $112.77. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $113.015 to $114.010. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. Represents the weighted average sales price per share. These shares were sold in multiple transactions at prices ranging from $115.345 to $116.150. The Reporting Person has provided to the Issuer, and undertakes to provide to the staff of the Securities and Exchange Commission or any security holder of the Issuer, upon request, full information regarding the number of shares sold at each separate price within the range. /s/ John G. Saia, as attorney-in-fact for Terilyn J. Monroe 2026-01-22