X0508 4 2026-01-15 0 0001576280 Guardant Health, Inc. GH 0001652956 Monroe Terilyn J. 3100 HANOVER STREET PALO ALTO CA 94304 0 1 0 0 Chief People Officer 0 Common Stock 2026-01-15 4 M 0 17379 0 A 38369 D Common Stock 2026-01-15 4 F 0 8808 111.98 D 29561 D Restricted Stock Units 0 2026-01-15 4 M 0 17379 0 D Common Stock 17379 17379 D These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability. This represents a restricted stock unit award granted on February 26, 2024 that vests over a three-year period. 33% of the shares subject to such award vested on the one-year anniversary of January 15, 2024 and the remaining 67% of the shares vest annually over the remaining two-year period, thereafter. Not applicable for Restricted Stock Units. /s/ John G. Saia, as attorney-in-fact for Tarilyn J. Monroe 2026-01-16