X0508 4 2026-01-01 0 0001576280 Guardant Health, Inc. GH 0001652956 Monroe Terilyn J. 3100 HANOVER STREET PALO ALTO CA 94304 0 1 0 0 Chief People Officer 0 Common Stock 2026-01-01 4 M 0 14896 0 A 35886 D Common Stock 2026-01-01 4 M 0 2659 0 A 38545 D Common Stock 2026-01-01 4 F 0 7524 102.14 D 31021 D Performance-Based Restricted Stock Units 0 2026-01-01 4 M 0 14896 0 D Common Stock 14896 14898 D Restricted Stock Units 0 2026-01-01 4 M 0 2659 0 D Common Stock 2659 18615 D These shares were retained by the Company in order to meet the tax withholding obligations of the award-holder in connection with the vesting of an installment of the restricted stock units. The amount retained by the Company was not in excess of the amount of the tax liability. This represents a performance-based restricted stock unit award granted on February 26, 2024, that a performance metric was achieved and that 33% of the shares subject to such award vested on March 1, 2025. 33% of the shares subject to the award vested on January 1, 2026, and the remaining 34% of the shares subject to the award will vest on January 1, 2027. Not applicable for Restricted Stock Units. This represents a restricted stock unit award granted on November 8, 2024 that vests over a three-year period. 33% of the shares subject to such award vested on October 1, 2025 and the remaining 67% of the shares vests in equal quarterly installments over the remaining two-year period thereafter. Table I includes 70 shares acquired under Guardant Health's Employee Stock Purchase Plan on 11/14/2025. /s/ John G. Saia, as attorney-in-fact for Tarilyn J. Monroe 2026-01-05