X0609 4 2026-09-23 0001604821 Natera, Inc. NTRA 0001646649 Sheena Jonathan false C/O NATERA, INC. 13011 MCCALLEN PASS BUILDING A SUITE 100 AUSTIN TX 78753 true false false true CO-FOUNDER 1 Common Stock 221314 D Common Stock 2026-09-23 4 S 0 400 385.1025 D 17632 I By Caraluna 1 Trust Common Stock 2026-09-23 4 S 0 2175 386.7144 D 15457 I By Caraluna 1 Trust Common Stock 2026-09-23 4 S 0 2734 387.6545 D 12723 I By Caraluna 1 Trust Common Stock 2026-09-23 4 S 0 1293 388.7071 D 11430 I By Caraluna 1 Trust Common Stock 2026-09-23 4 S 0 2320 389.6850 D 9110 I By Caraluna 1 Trust Common Stock 2026-09-23 4 S 0 110 390.42 D 9000 I By Caraluna 1 Trust Common Stock 2026-09-23 4 S 0 390 385.2906 D 17642 I By Caraluna 2 Trust Common Stock 2026-09-23 4 S 0 2300 386.6396 D 15342 I By Caraluna 2 Trust Common Stock 2026-09-23 4 S 0 2846 387.7351 D 12496 I By Caraluna 2 Trust Common Stock 2026-09-23 4 S 0 1341 388.7637 D 11155 I By Caraluna 2 Trust Common Stock 2026-09-23 4 S 0 1935 389.7108 D 9220 I By Caraluna 2 Trust Common Stock 2026-09-23 4 S 0 220 390.5250 D 9000 I By Caraluna 2 Trust The sale of shares was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 11, 2026. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $385.0350 to $385.1900 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Held for the benefit of the beneficiaries of the trust. The Reporting Person disclaims beneficial ownership over such securities. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $386.1750 to $387.1700 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $387.21 to $388.12 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $388.3050 to $389.0400 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $389.3650 to $390.2850 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $385.0350 to $386.0150 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $386.17 to $387.16 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $387.21 to $388.19 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $388.35 to $389.33 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $389.3650 to $390.2050 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $390.42 to $390.63 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. /s/ Tami Chen, Attorney-in-Fact 2026-09-25