X0609 4 2026-09-15 0001604821 Natera, Inc. NTRA 0001646649 Sheena Jonathan false C/O NATERA, INC. 13011 MCCALLEN PASS BUILDING A SUITE 100 AUSTIN TX 78753 true false false true CO-FOUNDER 1 Common Stock 2026-09-15 4 S 0 6000 350.0718 D 224464 D Common Stock 2026-09-16 4 S 0 200 348.0250 D 224264 D Common Stock 2026-09-16 4 S 0 100 349.0450 D 224164 D Common Stock 2026-09-16 4 S 0 1400 353.83 D 222764 D Common Stock 2026-09-16 4 S 0 450 354.9133 D 222314 D Common Stock 2026-09-16 4 S 0 800 355.9475 D 221514 D Common Stock 2026-09-16 4 S 0 200 356.8664 D 221314 D Common Stock 18032 I By Caraluna 1 Trust Common Stock 18032 I By Caraluna 2 Trust The sale of shares was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on December 12, 2025. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $350.00 to $350.1750 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $353.2700 to $354.2450 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $354.54 to $355.44 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $355.7350 to $356.6550 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $356.7150 to $357.0600 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. Held for the benefit of the beneficiaries of the trust. The Reporting Person disclaims beneficial ownership over such securities. /s/ Tami Chen, Attorney-in-Fact 2026-09-17