X0508 4 2026-01-20 0001604821 Natera, Inc. NTRA 0001646649 Sheena Jonathan C/O NATERA, INC. 13011 MCCALLEN PASS BUILDING A SUITE 100 AUSTIN TX 78753 true false false true CO-FOUNDER 1 Common Stock 22532 I By Caraluna 1 Trust Common Stock 22532 I By Caraluna 2 Trust Common Stock 2026-01-20 4 S 0 2981 234.7384 D 267050 D Common Stock 2026-01-20 4 M 0 191 A 267241 D Common Stock 2026-01-21 4 S 0 93 235 D 267148 D Common Stock 2026-01-21 4 S 0 2470 234.1157 D 264678 D Common Stock 2026-01-21 4 S 0 600 235.8183 D 264078 D Restricted Stock Unit 2026-01-20 4 M 0 191 0 D Common Stock 191 0 D The sale of shares was effected in order to satisfy tax withholding and remittance obligations in connection with the vesting of Restricted Stock Units (RSUs) and made pursuant to a written instruction that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act contained in the Reporting Person's Stock Unit Agreement granted on January 27, 2023. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The sale of shares was effected in order to satisfy tax withholding and remittance obligations in connection with the vesting of Restricted Stock Units (RSUs) and made pursuant to a written instruction that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c) under the Exchange Act contained in the Reporting Person's Stock Unit Agreement granted on January 28, 2022. The sale of shares was effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 7, 2024. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $234.04 to $234.87 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $235.5650 to $236.1850 per share, inclusive. The holder undertakes to provide, upon written request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The RSUs vest over four years. 25% of the RSUs vested on January 20, 2023 and the remaining shares vest in 12 equal quarterly installments thereafter. /s/ Tami Chen, Attorney-in-Fact 2026-01-22