X0508 4 2026-01-09 0 0001636282 Spyre Therapeutics, Inc. SYRE 0001794898 King-Jones Heidy 221 CRESCENT STREET, BUILDING 23, SUITE 105 WALTHAM MA 02453 0 1 0 0 See Remarks 0 Stock Option (Right to Buy) 30.61 2026-01-09 4 A 0 140000 0 A 2036-01-09 Common Stock 140000 140000 D This option represents a right to purchase 140,000 shares of the Issuer's common stock, which will vest in equal monthly installments over four years, subject to the Reporting Person's continued employment with the Issuer at each vesting date. Chief Legal Officer and Corporate Secretary /s/ Heidy King-Jones 2026-01-13