X0508 4 2025-12-12 0001566044 VYNE Therapeutics Inc. VYNE 0001632295 Little Elisabeth Sandoval C/O VYNE THERAPEUTICS INC. P.O. BOX 125 STEWARTSVILLE NJ 08886 true false false false 0 Stock Option (right to buy) 0.3756 2025-12-12 4 A 0 20000 0 A 2035-12-11 Common Stock 20000 20000 D Represents the annual award to non-employee directors of the Issuer, awarded on the date of the Issuer's annual meeting of stockholders. The shares subject to the option vest on December 12, 2026, subject to the Reporting Person's continuous service through such date. /s/ Mutya Harsch, Attorney-in-Fact 2025-12-15