X0609 4 2026-09-09 0 0001157601 MADRIGAL PHARMACEUTICALS, INC. MDGL 0001518611 Sibold William John false C/O MADRIGAL PHARMACEUTICALS, INC. 1001 CONSHOHOCKEN STATE ROAD SUITE 2-350 WEST CONSHOHOCKEN PA 19428 1 1 0 0 President and CEO 1 Common Stock 2026-09-09 4 S 0 131 527.8783 D 209198 D Common Stock 2026-09-09 4 S 0 347 529.2671 D 208851 D Common Stock 2026-09-09 4 S 0 522 530.2311 D 208329 D Common Stock 2026-09-09 4 S 0 368 531.9897 D 207961 D Common Stock 2026-09-09 4 S 0 512 533.0932 D 207449 D Common Stock 2026-09-09 4 S 0 396 534.1964 D 207053 D Common Stock 2026-09-09 4 S 0 644 535.2719 D 206409 D Common Stock 2026-09-09 4 S 0 1040 536.1123 D 205369 D Common Stock 2026-09-09 4 S 0 640 537.1738 D 204729 D Common Stock 2026-09-09 4 S 0 520 538.2971 D 204209 D Common Stock 2026-09-09 4 S 0 215 539.0281 D 203994 D Common Stock 2026-09-09 4 S 0 505 540.1909 D 203489 D Common Stock 2026-09-09 4 S 0 362 541.6538 D 203127 D Common Stock 2026-09-09 4 S 0 160 542.5475 D 202967 D Common Stock 2026-09-11 4 S 0 60 533.0913 D 202907 D Common Stock 2026-09-11 4 S 0 106 534.063 D 202801 D Common Stock 2026-09-11 4 S 0 218 535.9435 D 202583 D Common Stock 2026-09-11 4 S 0 160 537.6175 D 202423 D Common Stock 2026-09-11 4 S 0 687 540.5857 D 201736 D Common Stock 2026-09-11 4 S 0 368 541.6423 D 201368 D Common Stock 2026-09-11 4 S 0 1202 542.6032 D 200166 D Common Stock 2026-09-11 4 S 0 1539 544.024 D 198627 D Common Stock 2026-09-11 4 S 0 761 544.8307 D 197866 D Common Stock 2026-09-11 4 S 0 120 546.3767 D 197746 D This sale represents the number of shares sold by the Issuer on behalf of the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. This sale was automatic and not at the discretion of the Reporting Person. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $527.49 to $528.27, inclusive. The reporting person undertakes to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote and the footnotes below. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $528.54 to $529.51, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $529.64 to $530.48, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $531.57 to $532.28, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $532.57 to $533.29, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $533.58 to $534.57, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $534.63 to $535.62, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $535.64 to $536.45, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $536.64 to $537.56, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $537.70 to $538.65, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $538.86 to $539.83, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $539.86 to $540.47, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $541.29 to $542.27, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $542.42 to $542.68, inclusive. These sales were effected automatically pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on June 5, 2026. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $532.76 to $533.64, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $533.76 to $534.48, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $535.52 to $536.02, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $537.235 to $538.00, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $539.97 to $540.90, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $541.00 to $541.73, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $542.11 to $543.02, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $543.27 to $544.20, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $544.38 to $545.32, inclusive. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $546.28 to $546.56, inclusive. /s/ Mardi Dier, as Attorney-in-Fact 2026-09-11