X0609 4 2026-08-17 0 0001157601 MADRIGAL PHARMACEUTICALS, INC. MDGL 0002034056 Kelley Shannon T false C/O MADRIGAL PHARMACEUTICALS, INC. 1001 CONSHOHOCKEN STATE ROAD SUITE 2-350 WEST CONSHOHOCKEN PA 19428 0 1 0 0 General Counsel 0 Common Stock 2026-08-17 4 S 0 664 514.97 D 11474 D This sale represents the number of shares sold by the Issuer on behalf of the Reporting Person to cover tax withholding obligations in connection with the vesting of restricted stock units. This sale was automatic and not at the discretion of the Reporting Person. /s/ Mardi Dier, as Attorney-in-Fact 2026-08-20