X0609 4 2026-06-24 0 0001655759 ARVINAS, INC. ARVN 0001589602 Smaldone Alsup Laurie false C/O ARVINAS, INC. 5 SCIENCE PARK, 395 WINCHESTER AVE. NEW HAVEN CT 06511 1 0 0 0 0 Common Stock 2026-06-24 4 A 0 15527 0 A 41572 D Stock Option (right to buy) 8.05 2026-06-24 4 A 0 22714 0 A 2036-06-23 Common Stock 22714 22714 D The restricted stock units (each, an "RSU") were granted by the Issuer on June 24, 2026 and each RSU represents a contingent right to receive one share of the Issuer's common stock upon settlement for no consideration. The RSUs shall vest in full on the earlier of (i) June 24, 2027 or (ii) immediately prior to the first annual meeting of stockholders occurring after the date of grant, subject to the reporting person's continued service with the Issuer on the vesting date. This option award was granted on June 24, 2026. The shares underlying the award shall vest in full on the earlier of (i) June 24, 2027 or (ii) immediately prior to the first annual meeting of stockholders occurring after the date of grant, subject to the reporting person's continued service with the Issuer on the vesting date. /s/ Jared Freedberg, as attorney-in-fact for Laurie Smaldone Alsup 2026-06-26