X0609 4 2026-03-31 0 0001516551 Skye Bioscience, Inc. SKYE 0001425052 DHILLON PUNIT false 11250 EL CAMINO REAL, SUITE 100 C/O SKYE BIOSCIENCE, INC. SAN DIEGO CA 92130 1 1 0 0 Chief Executive Officer 0 Stock Option (Right to Buy) 0.615 2026-03-31 4 A 0 250000 A 2035-02-25 Common Stock 250000 250000 D Stock Option (Right to Buy) 2.89 2026-03-31 4 D 0 250000 D 2035-02-25 Common Stock 250000 0 D Stock Option (Right to Buy) 0.615 2026-03-31 4 A 0 36000 A 2030-08-07 Common Stock 36000 36000 D Stock Option (Right to Buy) 11.25 2026-03-31 4 D 0 36000 D 2030-08-07 Common Stock 36000 0 D Stock Option (Right to Buy) 0.615 2026-03-31 4 A 0 12360 A 2031-12-14 Common Stock 12360 12360 D Stock Option (Right to Buy) 14.50 2026-03-31 4 D 0 12360 D 2031-12-14 Common Stock 12360 0 D Stock Option (Right to Buy) 0.615 2026-03-31 4 A 0 650000 A 2034-10-27 Common Stock 650000 650000 D Stock Option (Right to Buy) 5.15 2026-03-31 4 D 0 650000 D 2034-10-27 Common Stock 650000 0 D Stock Option (Right to Buy) 0.615 2026-03-31 4 A 0 125000 A 2034-03-01 Common Stock 125000 125000 D Stock Option (Right to Buy) 14.56 2026-03-31 4 D 0 125000 D 2034-03-01 Common Stock 125000 0 D Stock Option (Right to Buy) 0.615 2026-03-31 4 A 0 9013 A 2033-11-06 Common Stock 9013 9013 D Stock Option (Right to Buy) 3.50 2026-03-31 4 D 0 9013 D 2033-11-06 Common Stock 9013 0 D Stock Option (Right to Buy) 0.615 2026-03-31 4 A 0 21586 A 2033-09-29 Common Stock 21586 21586 D Stock Option (Right to Buy) 3.50 2026-03-31 4 D 0 21586 D 2033-09-29 Common Stock 21586 0 D The exercise price of the stock option is $0.615 per share, representing the closing price of the Issuer's common stock on the date of the repricing. The stock option is fully vested. On March 31, 2026, the board of directors of the Issuer approved the one-time repricing of the stock option effective as of March 31, 2026. Except as described in footnote 1, all other terms of the stock option remain unchanged. The stock option vests in equal monthly installments over the four year period beginning October 28, 2024. The grant date for the stock option is October 27, 2024. Upon a change of control of the Issuer, 100% of the stock option will become fully vested. The stock option vests in equal monthly installments over the four year period beginning February 29, 2024. The grant date for the stock option is March 1, 2024. Upon a change in control of the Issuer, 100% of the stock options will become fully vested. The stock option vests in equal monthly installments over the four year period beginning August 24, 2023. The grant date for the stock option is November 6, 2023. Upon a change in control of the Issuer, 100% of the stock option will become fully vested The stock option vests in equal monthly installments over the four year period beginning August 24, 2023. The grant date for the stock option is August 25, 2023. Upon a change in control of the Issuer, 100% of the stock option will become fully vested. /s/ Punit S. Dhillon 2026-04-02