X0609 4 2026-03-16 0 0001658247 Crinetics Pharmaceuticals, Inc. CRNX 0001746298 Struthers Richard Scott C/O CRINETICS PHARMACEUTICALS, INC. 6055 LUSK BOULEVARD SAN DIEGO CA 92121 1 1 0 0 President & CEO 1 Common Stock 2026-03-16 4 S 0 13196 37.11 D 413563 D Common Stock 2026-03-16 4 S 0 8785 37.77 D 404778 D Common Stock 661205 I By Family Trust 1 Common Stock 106000 I By Family Trust 2 Common Stock 110000 I By Family Trust 3 Common Stock 100000 I By Family Trust 4 Common Stock 1000 I By Spouse Represents the number of shares of common stock sold by the Issuer to cover the Reporting Person's tax withholding obligation upon the vesting of Restricted Stock Units granted on February 28, 2022, March 1, 2023, and March 4, 2024. The disposition reported in this Form 4 was effected by a broker pursuant to instructions set forth in a Rule 10b5-1 trading plan adopted by the Reporting Person. The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $37.11 per share. The range of sales prices on the transaction date was $36.42 to $37.38 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request. The common stock was sold in open market transactions on the transaction date, with a volume weighted average sales price of $37.77 per share. The range of sales prices on the transaction date was $37.42 to $38.23 per share. Detailed information on the exact number of shares can be obtained from the Issuer upon request. /s/ Tobin Schilke, as attorney-in-fact 2026-03-18