X0508 4 2026-03-09 0 0001854270 Senti Biosciences, Inc. SNTI 0001852301 Lu Timothy K C/O SENTI BIOSCIENCES, INC. 2 CORPORATE DRIVE FIRST FLOOR SOUTH SAN FRANCISCO CA 94080 1 1 0 0 CEO 0 Common Stock 2026-03-09 4 F 0 80666 0 D 639583 D Common Stock 52839 I By spouse Common Stock 52839 I See footnote Represents the number of shares of common stock that have been withheld by the Issuer to satisfy its income tax withholding and remittance obligations in connection with the net settlement of certain time-based restricted stock unit awards and does not represent an open market sale. The shares are held by Luminen Services, LLC, as trustee of the Luminen Trust, of which the reporting person is the settlor. The reporting person disclaims Section 16 beneficial ownership of the securities, except to the extent of his pecuniary interest therein, if any, and this report shall not be deemed to be an admission that he has beneficial ownership of such shares for Section 16 or any other purpose. /s/ Robert Cutler, attorney-in-fact 2026-03-09