X0508 4 2026-02-17 0 0001357874 PRECISION BIOSCIENCES INC DTIL 0001830874 Amoroso Michael C/O PRECISION BIOSCIENCES, INC. 302 E. PETTIGREW STREET, SUITE A-100 DURHAM NC 27701 1 1 0 0 President and CEO 1 Common Stock 2026-02-17 4 M 0 67797 0 A 263951 D Common Stock 2026-02-18 4 S 0 20559 3.84 D 243392 D Restricted Stock Units 2026-02-17 4 M 0 67797 0 D Common Stock 67797 135593 D Represents the vesting of Restricted Stock Units ("RSUs") on February 17, 2026. Each RSU represents a contingent right to receive one share of the Issuer's Common Stock. The sales were effected pursuant to a Rule 10b5-1 plan adopted on August 2, 2024. The transaction was a sell-to-cover, with shares only sold to cover tax withholding obligations in connection with the vesting and settlement of RSUs. The Reporting Person did not sell or otherwise dispose of shares reported on this Form 4 for any reason other than to cover required taxes and fees. RSUs vests in three substantially equal annual installments beginning on February 17, 2026, subject to the Reporting Person's continued service to the Issuer through the applicable vesting dates. /s/ Dario Scimeca, Attorney-in-Fact for Michael Amoroso 2026-02-19