X0508 4 2026-02-13 0 0001655759 ARVINAS, INC. ARVN 0002026306 Cacace Angela M C/O ARVINAS, INC. 5 SCIENCE PARK, 395 WINCHESTER AVE. NEW HAVEN CT 06511 0 1 0 0 Chief Scientific Officer 0 Common Stock 2026-02-13 4 S 0 4592 11.89 D 151232 D This sale was made automatically by the Issuer to cover tax withholding obligations in connection with the vesting and settlement of 25% of the reporting person's restricted stock units (RSUs) granted on February 13, 2025. The sale does not represent a discretionary trade. Includes an aggregate of 1,576 shares of common stock of the Issuer previously purchased under and in accordance with the 2018 Employee Stock Purchase Plan of the issuer in transactions exempt under Rule 16b-3. /s/ Jared Freedberg, as attorney-in-fact for Angela M. Cacace 2026-02-18